“Alli” is FDA approved, but will it knock out obesity?

The FDA approved a 60mg dosage of orlistat to be sold over-the-counter (OTC) as Alli. Orlistat is a lipase-inhibitor designed to prevent the absorption of fat into the body. Clinical studies had proven orlistat’s effectiveness in preventing weight re-gain and weight loss, but only in conjunction with a reduced-calorie, low-fat diet and regular exercise. Although 120mg orlistat has been available for nearly a decade in prescription form (i.e. Xenical), Alli represents the first time the FDA has approved any weight loss aid for OTC use. Needless to say, it has generated some controversy. According to GlaxoSmithKlein, which manufacturers the drug, Alli will help people lose about 50% more weight than dieting alone. Researchers claim that participants lost on average 5 to 10 pounds over 6 months using diet, exercise and Alli. Interestingly, this only represented a 2 to 4 pound greater weight loss compared to controls. This has medical professionals wondering whether taking Alli is worth the risk of certain uncomfortable side effects or the $12 to $25 it will cost per week. Common side effects of Alli include: bowel changes, gas with oily spotting, loose stools, and more frequent stools that may be difficult to control. GlaxoSmithKlein recommends keeping fat intake to less than 15 grams per meal to reduce the risk of these effects. Some physicians have expressed concern over Alli because they suspect an increased risk for colon cancer. The general medical consensus is, however, that it will likely be limited in harm. On the other hand, the medical community also speculates that it will also be limited in the amount of good it does. If you're considering using Alli, you should consult a physician to determine whether on not it is appropriate. Also, as a lipase-inhibitor, Alli may reduce the absorption of some fat-soluble vitamins (A, D, E and K) and beta-carotene. Anyone taking Orlistat should be advised to eat plenty of fruits and vegetables in addition to taking a daily multi-vitamin to ensure adequate nutrient intake.